Poly-L-lactic acid (PLLA) microspheres

Introduction

Poly(L-lactic acid) (PLLA) Microspheres refer to PLLA in microsphere form. Their mechanism of action involves the hydrolytic degradation of PLLA in the skin, producing L-lactic acid—a naturally occurring substance in the body that is highly safe and ultimately metabolized into carbon dioxide and water. L-lactic acid interacts with dermal fibroblasts, stimulating the production of type III and type I collagen.

Product Details


































Product Name



Poly-L-lactic acid (PLLA) microspheres



Test Items



Method



Test Requirement



Inherent Viscosity



Chloroform , 25°C



0.5–1.5 dL/g



Moisture Content



Karl Fischer Titration



≤0.5%



 



Particle Size Specification



 



Laser Particle Size Analyzer



≤20μm;



20μm~50μm;



50μm~80μm。



Particle Size



Laser Particle Size Analyzer



≤0.5




 



If the product you need is not listed in the table above, please contact us for customization.



        



Function Overview:



 



Stimulates Collagen Production:

After subcutaneous injection, PLLA microspheres are absorbed by the body, releasing poly-L-lactic acid, which stimulates collagen production in the skin, thereby improving skin elasticity and firmness.



Wrinkle Filling:



Due to the size and shape of PLLA microspheres, they can be used to fill facial wrinkles and smooth uneven skin texture, making the skin appear smoother.



Long-Lasting Effects:

Unlike conventional fillers, PLLA microspheres stimulate collagen production, resulting in longer-lasting effects, typically lasting from several months to several years, offering durable aesthetic benefits.



 



Product Advantages:




  1. High particle size uniformity with precise controllability to obtain microspheres of varying sizes; good monodispersity.

  2. Independent spherical formation, high drug encapsulation efficiency.

  3. Gentle sphere formation with low shear and low temperature, avoiding drug damage.

  4. Continuous spheronization, no inter-batch variation.

  5. Wide range of drug loading, covering various molecular weights and drug types; capable of forming complex structured microspheres (e.g., porous, core–shell)

  6. Precise control of sustained-release cycle, easier to extend drug half-life and improve bioavailability compared with structural modification.

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